pantprazole concentration animalOverview of Using Pantoprazole in Dogs and Cats
Pantoprazole, commonly known by brand names like Protonix® and Pantoloc®, is a medication used to prevent and treat stomach ulcers and conditions related to excessive gastric acid in dogs and cats. While it has been a staple in human medicine for years, its use in veterinary care is becoming more widespread.
Typically, the stomach produces acid to aid digestion. However, under certain conditions, this acid can damage the stomach lining (mucosa), leading to ulcers or erosions (often described as “scratches” on the stomach lining). One of the most common causes of ulcers in both humans and animals is the use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.
pantprazole concentration animalhen there’s a risk of ulcer formation, there are several treatment options to heal the stomach or protect its lining. These can include antacids (like Maalox®), H2 blockers (such as Pepcid AC®), proton pump inhibitors (like Prilosec®), and prostaglandin analogs, including Misoprostol and Pantoprazole.
pantprazole concentration animalPantoprazole works by reducing stomach acid production and has a protective effect on both blood flow and the stomach lining, helping to prevent further damage. Although Pantoprazole is a prescription-only drug for pets and must be prescribed by a veterinarian, it is not officially approved by the FDA for use in animals. However, veterinarians can legally prescribe it for off-label use, offering a valuable tool for managing digestive health in pets.
Brand Names of Pantoprazole
pantprazole concentration animalPantoprazole is currently registered for use in humans only, with well-known formulations like Protonix® and Pantoloc®. While this medication has proven effective in human medicine, there are no specific veterinary formulations available. Pets who are prescribed Pantoprazole typically receive the human version, used under the guidance of a veterinarian for off-label purposes.
Uses of Pantoprazole (Protonix®, Pantoloc®) for Dogs
pantprazole concentration animalPantoprazole is commonly used to prevent and treat stomach ulcers. Human studies have also shown that pantoprazole may help combat Helicobacter pylori, a type of bacteria often linked to ulcer formation. This makes it a valuable treatment option not only for ulcers but also for addressing bacterial infections that contribute to digestive issues.
Precautions and Side Effects
pantprazole concentration animalPantoprazole is generally safe and effective when prescribed by a veterinarian, but like any medication, it can cause side effects in some animals. It should not be used in pets with a known allergy or hypersensitivity to the drug. Additionally, Pantoprazole can interact with other medications your pet may be taking. It’s important to consult with your veterinarian to check for potential interactions with drugs such as certain antifungals (like ketoconazole and itraconazole), iron supplements, thyroid medications, sucralfate, and warfarin. One of the most common side effects of Pantoprazole is diarrhea.
How Pantoprazole Is Supplied
pantprazole concentration animalPantoprazole is available in several forms to suit different treatment needs. It comes in delayed-release tablets in 20 mg and 40 mg doses, as well as an oral suspension at 40 mg. Additionally, it is available as an injectable solution in 40 mg vials (Protonix I.V.®). When reconstituted, the injectable form remains stable at room temperature for up to two hours. If diluted, it can stay stable for up to 22 hours at room temperature. These various options make it versatile for different types of treatment regimens.
Dosing Information of Pantoprazole (Protonix) for Dogs
pantprazole concentration animal Before administering any medication to your pet, always consult with your veterinarian. If you’re concerned about the cost of medication, pet insurance may be able to help—click here to learn more.
Pantoprazole should ideally be given with food, first thing in the morning. It’s important not to break or cut the tablets. The typical dosage is 0.3 to 0.45 mg per pound (0.7 to 1 mg/kg) once daily, and it can be administered either orally or intravenously (IV). If given IV, it should be administered slowly over 15 minutes. Pantoprazole should never be given intramuscularly (IM) or subcutaneously (SQ).
The length of treatment depends on the condition being treated, how your pet responds to the medication, and any potential side effects. It’s crucial to complete the entire prescribed course of medication, even if your pet seems to be feeling better, unless your veterinarian advises otherwise. This ensures that the condition is fully addressed and reduces the risk of relapse.
References and Resources
pantprazole concentration animal For those seeking more in-depth information on the effects of various medications like ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs, the study by Bersenas A. published in the American Journal of Veterinary Research (AJVR) in 2005 provides valuable insights. Additionally, reliable resources such as the ASPCA Pet Poison Hotline, the Textbook of Veterinary Internal Medicine by Ettinger and Felman, Current Veterinary Therapy XV by Bonagura and Twedt, and Plumb’s Veterinary Handbook (9th Edition) by Donald C. Plumb, offer comprehensive guidance on veterinary care and drug interactions. For pet poison emergencies, the Pet Poison Helpline is also an important resource.
